An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
نویسندگان
چکیده
منابع مشابه
An inherited mutation in NLRC4 causes autoinflammation in human and mice
Autoinflammatory syndromes cause sterile inflammation in the absence of any signs of autoimmune responses. Familial cold autoinflammatory syndrome (FCAS) is characterized by intermittent episodes of rash, arthralgia, and fever after exposure to cold stimuli. We have identified a missense mutation in the NLRC4 gene in patients with FCAS. NLRC4 has been known as a crucial sensor for several Gram-...
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www.japi.org 877 either endogenous reactivation of TB or predisposed our patient to exogenous reinfection. The extension of the malignant neoplasm from the lung parenchyma to the visceral pleura may have eroded a sub pleural focus of mycobacteria into the pleural space thus setting into motion the chain of events leading to the development of a tuberculous pleural effusion. RC Sahoo *, PR Achar...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2014
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.3089